Documentation and support

VOG workflow

Orthologous groups are a central resource for comparative virus (meta-)genomics. VOGDB, a continously updated resource of Virus Orthologous Groups (VOG), is based all RefSeq virus genomes and thus represents all viral lineages of which complete genomes are available. A schematic workflow is shown on the right. VOG release numbers are equivalent to the RefSeq release numbers they are based on.

VOGDB provides specific tools for virus metagenomics:

  1. Virus specific groups: VOG without homology to cellular genomes are labeled as virus-specific markers. They allow to identify virus sequences in metagenomes (used e.g. in HoloVir) or pro-viruses in cellular (meta) genomes. Virus specific VOG are derived by using three different stringencies (high: no hits of E<1e-04 in more than 2 eukaryotic genomes; medium: no hits of E<1e-10 in more than 3 eukaryotic genomes; low: no hits of E<1e-15 in more than 4 eukaryotic genomes).
  2. Panels of essential groups: VOG which encode essential genes for viral lineages (such as for virus structure and replication) are grouped. These panels facilitate OTU-based diversity analysis. These groups are currently under construction and will be provided by mid 2017.

The manuscript for publication is in preparation. For all questions, suggestions and problem reports please contact us: contact.cube@univie.ac.at